Prescribing - What's all the fuss?

11. If necessary, alter prescription
The response may be to alter the dose, cease the medication, prescribe another agent or try alternative non-pharmacological approaches. If Lionel’s blood pressure does not meet targets, then the dose should be increased, and eventually a low dose thiazide should be added in.

Using a P-drug list
Now you may look at this and think it is far too much work for a 10 minute consultation! The important issue is that you only have to go through the process of choosing the correct drug for diabetic hypertensives once. You then add the ACE inhibitor that you have chosen to your P-drug list, and you prescribe it for all of your diabetic hypertensives from then on, unless there is a particular suitability issue. The choice takes a bit longer the first time, but it is then rational, appropriate and evidence based. It also has the benefit of saving time on future consultations because you know exactly what to prescribe. Also, when a new drug is being marketed for the treatment of hypertension, in order for it to become your first line treatment on your P-drug list, you have to see proof that it is better than the ACE inhibitor for diabetic patients. The angiotensin receptor antagonists have been shown recently to improve renal complications in diabetic patients with underlying nephropathy. However, these studies did not show a mortality benefit. Hence, you may wish to put an angiotensin receptor antagonist on your P-drug list for diabetic hypertensive patients with nephropathy.

 

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Table 1. Characteristics of good and bad prescribing (modified from 4)

  Good prescribing   Bad prescribing
 Effective  Ineffective
 Safe  Unsafe
 Patient centered and individualized  Not patient centered
 Acceptable to patient  Not suitable for patient
 Appropriate (not too little or too much)  Inappropriate
 Addresses expectations of patient  Causes patient distress & harm
 Judicious use of resources  Higher cost
 Well informed (evidence based)  Poorly informed
 Based on unbiased information  Based on biased information
 Low vulnerability to outside influences   Vulnerable to outside influence

Conclusion
Prescribing is an important behaviour that GPs regularly practice, but it has previously been poorly taught in medical schools. The WHO has developed a structured guide to good prescribing and the steps in this process are easy to learn and apply in day-to-day practice. Central to this process is the development of a personal formulary (P-drug list) where a limited number of
drugs are chosen for specific indications