HEALTH AND WELLNESS

The practical pharmacological approaches currently available for treatment of Alzheimers Disease include, cholinesterase inhibitors, antioxidants, e.g. Vitamin E, anti inflammatory agents, estrogen, seligiline, vasoactive agents and ginko biloba.

In the Commentary Combination Therapy for early Alzheimers Disease "What are we waiting for?" Doraiswamy and Setffens, Dept of Psychiatry and Behavourial Sciences, Dukes University Medical Centre recommend a combination of the aforementioned substances most of which would include cholinesterase inhibitors. They also make the point that the widespread use of multi-drug therapies, for Alzheimers Disease, without the evidence-based support, reflects a desperation of families and providers. This article was written in 1998, and appears to be totally unaware of the work of Dr Dharma Singh Khalsa, who had already provided a treatment protocol for patients with either brain degeneration or associated memory impairment, or dementia. His protocol included a combination of herbs, vitamins and pharmaceuticals, together with meditation, yogic and mental exercise programme.

APPENDIX
The Hormonal Cascade:

The body ages from the brain downward, from the pineal to the limbic system, to the pituitary, to the end organs. The cascade of hormones from the pituitary determines sexuality, emotions, intelligence and immunity. To offset aging and degeneration of the hormonal system hormones need to be replaced from the brain downward.

Replacement Substances
Level on Cascade Replacement Substance
Pineal Gland Melatonin
Hypothalamus Deprenyl
  Acetyl-Carnitine
Pituitary Growth Hormone
Adrenals DHEA
Testes Testosterone
Ovaries Estrogens
  Progesterone

Women suffer more from Alzheimers than men. They also live longer than men, and their life span is increasing significantly. Although women lose over 90% of their estrogen at menopause, men do not show much estrogen decline, with aging, as they have sufficient testosterone to convert to estrogen if required. Estrogen deficit reduces intelligence and memory and contributes toward dementia. Dr A Paganini-Hill and Dr. Victor Henderson in Los Angeles, found that women who were on estrogen replacement therapy had a much lower incidence of Alzheimers. A huge number of prescription drugs, produce impotence as a side effect and drugs interfere with the hormone cascade.