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Abstract
Background: PPIs are
frequently used in hospitals,
primary health care centers
and private clinics. The adverse
effects and interactions are
numerous so, physicians’
knowledge including accurate
indications after confirmations
of diagnosis, duration of
use and follow-up are an essential
part of the treatment process.
Aim:
The purpose of this review
tis o help health care professionals
to prescribe the PPIs wisely
and appropriately.
Objective:
To undertake a review of the
literature relating to the
long-term use of PPIs
Data
Sources: United States,
Food and Drug Administration
[FDA], PubMed, Scopus, Science
Direct, Wiley, Google Scholar,
major clinical guidelines,
and governmental agencies.
Data
Extraction: The 2 reviewers
Musa Basheer Mansour and Sara
Ahmedana [MBM and SEA] independently
assessed the qualities of
the extracted studies and
summarized data of the studies
for outcomes of interest and
performed quality assessments
based on review of published
articles and the data sources.
Results:
We reviewed the available
evidence and summarized the
long-term use of PPIs as indicated
by major clinical guidelines,
governmental agencies, and
published studies. For instance,
United States, Food and Drug
Administration, American Gastroenterological
Association, American Academy
of Family Physicians, British
National Formulary, National
Institutes of Health, Randomized
controlled trials, Systematic
review, Meta-analysis and
Observational studies.
Conclusion:
This review will provide clinical
practice with research evidence-based
guidelines. Clinicians and
physicians should follow the
major clinical guidelines
and governmental agencies
to prescribe PPIs, follow
their patients regularly to
achieve the goals of treatment,
to avoid adverse effects,
drug interactions and reduce
the costs.
Keywords:
Proton Pump Inhibitors,
Food and Drug Administration,
Gastrointestinal Acid Disorders,
Gastro-Esophageal Reflux Disorder,
and peptic ulcer disease
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