Key features of depression and its management in general practice.

 
"..I'm not like I was before"
Which of the following statements are true of the pharmacological treatment of major depression?
1. The majority of patients with major depression respond to antidepressant treatment.
2. All available antidepressants are equally effective if given at an adequate dose for a sufficient period.
3. Newer antidepressants and older antidepressants such as tricyclics or the monoamine oxidase inhibitors have an equal incidence of significant side effects.
4. Newer antidepressants have higher compliance rates than older drugs.
5. SSRIs are first-line treatment for depression requiring antidepressants.

5. SSRIs are first-line treatment for depression requiring antidepressants.

Author's answer: True

SSRIs have become the first-line treatment for depression. The principle rationale includes their safety in overdose and generally good tolerability. The most common side effects of the SSRIs are nausea, headache, insomnia, sedation, lack of appetite, and sexual dysfunction.

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