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Abstract
Vitamin
B12, also known as cobalamin,
is a water-soluble vitamin
primarily obtained from animal-based
foods. It is crucial for hematopoietic
cell formation, with methylcobalamin
and adenosylcobalamin being
its active forms. The metabolic
process involves stomach release,
binding to proteins, and absorption
in the ileum with intrinsic
factor. The liver stores B12,
but deficiency can occur due
to dietary, absorption, transportation,
or metabolic issues.
Causes
of low B12 levels include
dietary choices, gastrointestinal
diseases, and medications
likemetformin. Dermatological
changes associated with deficiency,
such as hyperpigmentation,
can occur, possibly due to
decreased glutathione and
increased melanin production.
Vitamin
B12 deficiency has a wide
range of symptoms, from asymptomatic
to severe neurological impairments,
but its dermatologic effects
have been under-represented
in literature.”
Keywords:
Vitamin B12 deficiency, dermatologic
manifestations
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