Authors:
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Dr.Ibrahim
Ayyad,MD
Dr.
Adnan Abu Omar,MD*.
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Correspondence:
Dr Ibrahim Ayyad.
P.O. Box 559
Jordan, Ramtha
E mail: ayyadibrahim@hotmail.com
Key words:
Abstract
Objective: To assess the effectiveness of rectally used
misoprostol in the prevention of postpartum hemorrhage compared with
oxytocin.
Materials and Methods: 402 women underwent analysis
and were randomized to receive either two 200 micrograms rectal misoprostol
tablets (study group) or 20 units oxytocin in 50 cc normal saline
intravenously (control group). Primary outcome measures were the incidence
of postpartum
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hemorrhage or a change in hematoctrit or hemoglobin
from admission to day one post delivery.
Results: The incidence of postpartum hemorrhage was
7% in the study subjects and 6% in the control subjects (P>0.05)
There were no significant difference among the groups in the drop
of hematocrit (P>0.05). Secondary outcome measures including severe
postpartum hemorrhage and the duration of the third stage of labour
were similar in both groups.
Conclusion: Rectal misoprostol is as effective as intravenous
oxytocin in preventing postpartum hemorrhage with the same incidence
of side effects and is recommended to be used as a uterotonic agent
for the routine management of third stage of labour.
 
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