|
Results
450 women were randomised, 218 to the misoprostol group and 232 to
the oxytocin group. 48 women were excluded from the study due to either
caesarean section or hypersensitivity to prostaglandins or had initial
haemoglobin <8mg %. After exclusion, 198 women received the study
medication and 204 women received the control medication.
Table 1 describes the demographic characteristics of subjects while
Table 2 describes the intraparum characteristics.
Table 1 Demographic Characteristics
|
Characteristic
|
Misoprostol group
n= 198
|
Oxytol in group
n= 204
|
p
|
|
Maternal age *(y)
|
23.5+/-4.3
|
23+/-4.9
|
0.280
|
|
Parity
Primapara*
Multyara*
|
93(47%)
105(53%)
|
98(48%)
106(52%)
|
0.830
|
|
Gestational age# (d)
|
277+/-28.7
|
272+/-31.2
|
0.059
|
|
Predelivery tib level#
(g/dl)
|
11.1+/-2.3
|
11.2+/-2.7
|
0.344
|
|
Predelivery hematocrit
#(%)
|
35+/-3.5
|
35.2+/-3.4
|
0.281
|
|
Anteparum blood transfusion*
|
2(1%)
|
3(1%)
|
0.173
|
Data are presented as mean
+ SD, unless otherwise indicated
*Not statistically significant deference among groups (p > 0.05)
X2 (chi- square test)
#Not statistically significant deference among groups (p > 0.05)
t-test (student test)
|
|
Table 2 Intrapartum Characteristics
|
Characteristic
|
Misoprostol
group
n= 218
|
Oxytol
in group
n= 232
|
p
|
|
Admitted in spontaneousLabour*
|
131(60%)
|
151(65%)
|
0.274
|
|
Required induction*
|
87(40%)
|
81(35%)
|
0.460
|
|
Route of delivery*
Vaginal
cls
|
196(90%)
22(10.1%)
|
207(89%)
252(11%)
|
0.812
|
|
Episiotomy#
|
11.1+/-1.3
|
11.2+/-2.6
|
0.301
|
Data are presented
as mean + SD, unless otherwise indicated
*Not statistically significant deference among groups (p > 0.05)
X2 (chi- square test)
#Not statistically significant deference among groups (p > 0.05)
t-test (student test)
There were no significant differences between
the groups with respect to their demographic or intrapartum characteristics.
The outcome measures of the trial treatment are described in Table
3.
Of the 402 women, 7% of the study subjects and 6% of the control subjects
had postpartum haemorrhage (P=0.628). A comparison of the drop in
Hb and hematocrit indicated that 1.4% of the study group and 1.3%
of the control subjects had 10% drop in Hb from admission to day one
postpartum (P=0.675).
 
|