Key features of depression
and its management in general practice. |
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"..I've
been possessed by the devil"
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| Which
of the following statements are true in relation to withdrawal of
Omar from his antidepressants? |
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1.
Carbamazepine is effective as long term prophylaxis. |
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2.
Sodium valproate is now used widely for maintenance treatment. |
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3.
Angiotensin converting enzyme inhibitors may cause lithium toxicity
in people taking the drug. |
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4.
Omar should have his thyroid function monitored every 6 to 12 months. |
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5.
Cessation of lithium should be gradual, over at least 1 to 2 months. |
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3.
Angiotensin converting enzyme inhibitors may cause lithium toxicity
in people taking the drug.
Author's
answer: True
Intercurrent
illness, fluid loss or use of diuretics, nonsteroidal anti-inflammatory
drugs or angiotensin converting enzyme inhibitors may reduce renal clearance
of lithium and lead to increased tissue concentrations and toxicity.
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