Key features of depression and its management in general practice.

 
"..I've been possessed by the devil"
Which of the following statements are true in relation to withdrawal of Omar from his antidepressants?
1. Carbamazepine is effective as long term prophylaxis.
2. Sodium valproate is now used widely for maintenance treatment.
3. Angiotensin converting enzyme inhibitors may cause lithium toxicity in people taking the drug.
4. Omar should have his thyroid function monitored every 6 to 12 months.
5. Cessation of lithium should be gradual, over at least 1 to 2 months.

3. Angiotensin converting enzyme inhibitors may cause lithium toxicity in people taking the drug.

Author's answer: True

Intercurrent illness, fluid loss or use of diuretics, nonsteroidal anti-inflammatory drugs or angiotensin converting enzyme inhibitors may reduce renal clearance of lithium and lead to increased tissue concentrations and toxicity.

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