 Key features of depression and its management in general practice. |
| "..Everything
is ok in that department.." |
| Which of the following statements are true in relation of this presentation? |
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1.
Discontinuation of an SSRI is not associated with a withdrawal syndrome.
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2.
Withdrawal of an SSRI may cause nausea and vomiting.
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3.
Withdrawal of an SSRI may cause life-threatening illness.
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4.
Tapering may be necessary when stopping an SSRI.
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5.
The withdrawal syndrome of an SSRI may be difficult to distinguish
from major depression.
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4. Tapering may be necessary when stopping an SSRI.
Author's answer: True
Tapering is generally not necessary at therapeutic doses (1). Patients receiving higher doses, those with a prior history of discontinuation symptoms and those who develop withdrawal symptoms when the antidepressant is ceased, may require tapering over 4 to 7 days or longer if discontinuation symptoms are severe.