JOURNAL
Current Issue
Journal Archive
.............................................................
April 2021 -
Volume 19, Issue 4


View this issue in pdf format

........................................................
From the Editor

Editorial
A. Abyad (Chief Editor)
........................................................

 

Original contribution

Caring for patients with cancer in Qatar: the impact on the mental health of voluntary caregiver
[pdf]
[Abstract]
Zeinab Idris, Asma Al bulushi, Khadra Yassin, Nima Ali, Hanan Zada,
Hafedh Ghazouani
DOI: 10.5742/MEWFM.2021.94020

Assessment of Patients' Comprehension of Discharge Instructions and Associated Factors
[pdf]
[Abstract]
Hasan M. Alzahrani, Safar A. Alsaleem, Lubna F. Abbag, Eman Saeed Salem, Shahad Awad Al-Qahtani, Bayan Mohammed Hanif Alqhatani, Malak Hadi Assiri
DOI: 10.5742/MEWFM.2021.94021

Prevalence of Obesity among King Khalid University students in, 2020, Saudi Arabia
[pdf]
[Abstract]
Shehata Farag Shehata, Basel Mohammed Althubait, Anas Ali AboTamrah, Khalid Mohammed Alotaibi, Khaled Abdulwahab Amer, Abdulrahman Ali Aldosari, Abdullah Ali BinZahif
DOI: 10.5742/MEWFM.2021.94022

Population and Community Studies

Relation of Islamic Religiosity to Resistance to Intellectual Temptation. A Study on a Sample of Youth in the Kingdom of Saudi Arabia
[pdf]
[Abstract]
Rugayah N M Nayaz, Tawfik A M Khoja, Waris Qidwai
DOI: 10.5742/MEWFM.2021.94024

Prevalence of Astigmatism among medical students in King Khalid University and its effects on academic performance
[pdf]
[Abstract]
Abdulrahman Al-Amri, Bushra Abdullah Almohi, Nora Khaled Al Walidi, Razan Shaker M. Asiri R
DOI: 10.5742/MEWFM.2021.94025

Study of post total knee replacement and outcome in Aden, Yemen
[pdf]
[Abstract]
Abdul Fatah Abbas Mansoor Haidarah
DOI: 10.5742/MEWFM.2021.94030

Reviews

Diagnostic Approach to Lymphadenopathy in children
[pdf]
[Abstract]
Ahmad Zaaza, Nidal Ibrahem Agha
DOI: 10.5742/MEWFM.2021.94026

The Effects of Digital Technology Usage on Children's Development and Health
[pdf]
[Abstract]
Nidal Ibrahem Agha, Ahmad ZaaZa
DOI: 10.5742/MEWFM.2021.94027

Relationship between autoimmune thyroid dysfunction and diabetes mellitus type 1 in pediatric population
[pdf]
[Abstract]
Samer Abdullatif Ali, Ghaleb Mohd Faisal Aref Abu Hwij
DOI: 10.5742/MEWFM.2021.94029

Liraglutide for Weight Management, Critical Analysis of Efficacy and Side effects in Non diabetic, individuals with obesity: A Comprehensive Systematic Review
[pdf]
[Abstract]
Sidra Kanwal, Elham Abdullah AlEmadi
DOI: 10.5742/MEWFM.2021.94031

Covid in the Region

The prevalence of COVID 19 among PHCC workers and its relation to place of works and medical comorbidities
[pdf]
[Abstract]
Ahmed Mohamed Kahlout, Khadijeh ALhubidi, Meshal Abdulla AlMesaifri, Tala AL Mansour, Hanan Khudadad
DOI: 10.5742/MEWFM.2021.94032

The COVID-19 Pandemic Impact on Primary Health Care Services: An Experience from Qatar
[pdf]
[Abstract]
Mohamed Ghaith Al-Kuwari, Mariam Ali Abdulmalik, Ahmad Haj Bakri, John Gibb, Mujeeb Chettiyam Kandy, Selvakumar Swamy, Samya Ahmad Al-Abdulla, Manal B Al-Zaidan
DOI: 10.5742/MEWFM.2021.94033

Outcome of COVID-19 among homecare patients and its relation to chronic diseases
[pdf]
[Abstract]
Ali Mohammad alqahtani, Faisal Mubarak Alshahrani, Mohamed M. Esmail Khalaf, Sameh Reda Rezk
DOI: 10.5742/MEWFM.2021.94035

Case Report

Management of Hemorrhagic Pancreatitis Secondary to Multiple Vascular Aneurysmal Rupture: A Case Report
[pdf]
[Abstract]
Emad A Fallatah, Ghader G Jamjoum, Mowadah W Ashgar, Adel Kotb, Reda A Jamjoom, Mohammed O Nassif, Marwan Al-Hajeili, Nora H Trabulsi
DOI: 10.5742/MEWFM.2021.94037

Original Clinical Research

Prevalence of Atopic Dermatitis and its Associated Factors Among 4-12-Month-Old Infants Attending Primary Health Care Corporation in Qatar
[pdf]
[Abstract]
Ahmed Mohamed Kahlout, Akeil Al Faraj, Majd Riad Akbik, Azzam Awad Ashour, Sundus Kadhim Abdulridhe, Wesam Abou Amer, Lolwa K M Al-Maslamani, Naheel Ismail Seyam, Tala Almansour, Hanan Khudadad
DOI: 10.5742/MEWFM.2021.94039

Role of BMI, Patient's psychological status and Implant type on Patient's Satisfaction after Total Knee Arthroplasty (TKA)
[pdf]
[Abstract]
Raed Wagokh, Ashraf Fowzat Omor, Laith Al Tarawnah, Nizar Al Berihi,
Moayad Mousa Abu Qa'oud
DOI: 10.5742/MEWFM.2021.94040


Middle East Quality Improvement Program
(MEQUIP QI&CPD)

Chief Editor -
Abdulrazak Abyad MD, MPH, MBA, AGSF, AFCHSE
.........................................................

Editorial Office -
Abyad Medical Center & Middle East Longevity Institute
Azmi Street, Abdo Center,
PO BOX 618
Tripoli, Lebanon
Phone: (961) 6-443684
Fax:     (961) 6-443685
Email: aabyad@cyberia.net.lb
.........................................................

Publisher -
Lesley Pocock
medi+WORLD International
AUSTRALIA
Email: lesleypocock@mediworld.com.au
.........................................................

Editorial Enquiries -
abyad@cyberia.net.lb
.........................................................

Advertising Enquiries -
lesleypocock@mediworld.com.au
.........................................................

While all efforts have been made to ensure the accuracy of the information in this journal, opinions expressed are those of the authors and do not necessarily reflect the views of The Publishers, Editor or the Editorial Board. The publishers, Editor and Editorial Board cannot be held responsible for errors or any consequences arising from the use of information contained in this journal; or the views and opinions expressed. Publication of any advertisements does not constitute any endorsement by the Publishers and Editors of the product advertised.

The contents of this journal are copyright. Apart from any fair dealing for purposes of private study, research, criticism or review, as permitted under the Australian Copyright Act, no part of this program may be reproduced without the permission of the publisher.
April 2021 - Volume 19, Issue 4

Liraglutide for Weight Management, Critical Analysis of Efficacy and Side effects in Non diabetic, individuals with obesity: A Comprehensive Systematic Review

Sidra Kanwal (1)
Elham Abdullah AlEmadi (2)

(1) MBBS,FCPS, MRCGP[INT] Specialist Family Medicine, Primary Health Care Corporation, Qatar
(2) MBBS, Arab board specialist, Primary Health Care Corporation, Qatar

Corresponding author:
Dr. Sidra Kanwal
Primary Health Care Corporation,
QatarPhone: +97450494237
Email: skanwal1986@yahoo.com

Received: February 2021; Accepted: March 2021; Published: April 1, 2021. Citation: Sidra Kanwal, Elham Abdullah Nusrullah AlEmadi. Liraglutide for Weight Management, Critical Analysis of Efficacy and Side effects in Non diabetic, individuals with obesity: A Comprehensive Systematic Review. World Family Medicine. 2021; 19(4): 72-83 DOI: 10.5742/MEWFM.2021.94031

Abstract


Objective: Liraglutide is a FDA approved pharmacological option of weight loss with admissible safety profile and generally considered as a safe therapeutic. However, almost all liraglutide based studies always reported a certain number of withdrawals and serious adverse events with its weight management effect. This study was designed to evaluate the efficacy, safety, and use of all doses of liraglutide for weight management in non-diabetic persons with obesity.

Methods: The literature search was performed using Cochrane advanced search using “liraglutide”, non-diabetic, weight loss, obese, and glucagon-like peptide-1 receptor agonist in different combinations. All randomized control trials, relevant to the inclusion criteria were selected for review writing.

Results: Nine randomized controlled trials of all doses of liraglutide for weight management in non-diabetic, obese individuals were identified. Most of the trials were based on liraglutide 3.0 mg, other doses were 1.2, 1.8, and 2.4 mg. All trials concluded that the greater proportion of participants achieved about 5-10% weight loss. Trials carried out with all doses of liraglutide, concluded dose 3.0 had better weight loss outcomes. Reduction of cardiovascular risks was the most reported benefit of liraglutide administration.
The common adverse events were gastrointestinal and usually occurred in the early phase of treatment during dose escalation. The only associated concern was serious adverse events such as Pancreatitis, Cancer, Psychiatric Effects linked with all doses of liraglutide, particularly dose 3.0 and associated withdrawals.

Conclusion: All doses of liraglutide are effective in weight loss in non-diabetic, obese individuals; particularly dose 3.0 is the most effective one. Generally, liraglutide is safe for most study participants with minor gastrointestinal adverse events. The only concern is its associated serious adverse events; although, experienced by very few.

Key words: Liraglutide, glucagon-like peptide, weight management, non-diabetic, obese







 


 
.................................................................................................................