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| From
the Editor |
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Editorial
A. Abyad (Chief Editor) |
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Original Contribution
Pattern and Frequency of Hospital Acquired
Infections in Pediatric Intensive Care Unit
at Abha Maternity and Children Hospital, Saudi
Arabia
[Abstract]
[pdf]
Mohamad M. Almasadi, Saleh M. Al-Qahtani, Ibrahim
Alhelali, Njood Alwadei, Asmahan Aasiri, Maryam
Alnabhan, Fatmah Alassiri, Kholoud Alomar
DOI: 10.5742MEWFM.2020.93839
Emergency Physician Practice of laboratory
tests requesting at King Faisal Hospital Taif,
KSA, 2020
[Abstract]
[pdf]
Abdulsalam Alshehri , Maryam A. Alzaylaee, Afnan
S. ALgethami, Amjad W. Alotaibi, Hessa A. Alshahrani,
Shumukh K, Aburukbah
DOI: 10.5742MEWFM.2020.93840
The most desired values of high and low
density lipoproteins and triglycerides in the
plasma
[Abstract]
[pdf]
Mehmet Rami Helvaci, Mustafa Yaprak, Necmetin
Tasci, Abdulrazak Abyad, Lesley Pocock
DOI: 10.5742MEWFM.2020.93842
Quality of life of older patients attending
a general hospital in Baghdad/Iraq
[Abstract]
[pdf]
Maha Sulaiman Younis
DOI: 10.5742MEWFM.2020.93841
Physical activity profile among Saudi adults
in Abha City, Saudi Arabia
[Abstract]
[pdf]
Yousef Hussain Al Zahib, Hammam Baarimah
DOI: 10.5742MEWFM.2020.93843
Coronavirus Environment vs Socio-Economic
and Demographic Problems Followed: A Sociological
Appraisal
[Abstract]
[pdf]
Mohammad Taghi Sheykhi
DOI: 10.5742MEWFM.2020.93844
Flexible intramedullary nails for treatment
of femoral shaft fracture in children, Aden,
Yemen
[Abstract]
[pdf]
Abdulsalam Abdullah Hadi Mohsen
DOI: 10.5742MEWFM.2020.93845
Sodium-Glucose Cotransporter 2 Inhibitors
and its Renal benefits in type 2 diabetes. A
Systematic Review
[Abstract]
[pdf]
Saad Ur Rehman, Faiqa Rahman
DOI: 10.5742MEWFM.2020.93846
Parkinson's Disease: An update on Pathophysiology,
Epidemiology, Diagnosis and Management. Part
4 : Differential Diagnosis and Patient Assessment
[Abstract]
[pdf]
Abdulrazak Abyad
DOI: 10.5742MEWFM.2020.93847
Bloodstream infection with Kocuria rhizophila:
A case report and review of literature
[Abstract]
[pdf]
Njood M. Alwadei, Ibrahim Alhelali, Moustafa
S Mohame
DOI: 10.5742MEWFM.2020.93848
Knowledge, attitudes and awareness of women
about the long and short-term effects of a caesarean
section for mothers and children in Taif, KSA,
2020
[Abstract]
[pdf]
Ashwaq K. Al-Harthi, Shumukh K. Aburukbah ,
Afnan S. Algethami , Faten A. Kaabi ,
Abdullah M. Altalhi, Maryam A. Alzaylaee
DOI: 10.5742MEWFM.2020.93849
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Chief
Editor -
Abdulrazak
Abyad
MD, MPH, MBA, AGSF, AFCHSE
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Editorial
Office -
Abyad Medical Center & Middle East Longevity
Institute
Azmi Street, Abdo Center,
PO BOX 618
Tripoli, Lebanon
Phone: (961) 6-443684
Fax: (961) 6-443685
Email:
aabyad@cyberia.net.lb
.........................................................
Publisher
-
Lesley
Pocock
medi+WORLD International
AUSTRALIA
Email:
lesleypocock@mediworld.com.au
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Editorial
Enquiries -
abyad@cyberia.net.lb
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Advertising
Enquiries -
lesleypocock@mediworld.com.au
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While all
efforts have been made to ensure the accuracy
of the information in this journal, opinions
expressed are those of the authors and do not
necessarily reflect the views of The Publishers,
Editor or the Editorial Board. The publishers,
Editor and Editorial Board cannot be held responsible
for errors or any consequences arising from
the use of information contained in this journal;
or the views and opinions expressed. Publication
of any advertisements does not constitute any
endorsement by the Publishers and Editors of
the product advertised.
The contents
of this journal are copyright. Apart from any
fair dealing for purposes of private study,
research, criticism or review, as permitted
under the Australian Copyright Act, no part
of this program may be reproduced without the
permission of the publisher.
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| August 2020 -
Volume 18, Issue 8 |
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Sodium-Glucose
Cotransporter 2 Inhibitors and their Renal benefits
in type 2 diabetes. A Systematic Review
Saad Ur Rehman Faiqa Rahman
Consultant family physicians, Primary Health
Care Corporation, Doha, Qatar
Corresponding author:
Dr Saad Ur Rehman,
Primary Health care Corporation
Doha, QatarTel: 0097430199548
Email: saadrehman10@gmail.com
Received: June 2020; Accepted: July 2020; Published:
August 1, 2020. Citation: Saad Ur Rehman, Faiqa
Rahman. Sodium-Glucose Cotransporter 2 Inhibitors
and their Renal benefits in type 2 diabetes.
A Systematic Review. World Family Medicine.
2020; 18(8): 57-68 DOI: 10.5742MEWFM.2020.93846
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Abstract
Background: Existing
studies show that the hyperglycemia-reducing
effect of sodium-glucose cotransporter
2 inhibitor (SGLT2i) is dependent on glomerular
filtration. Previous studies have shown
that SGLT2 are not very effective in controlling
blood sugars in patients with impaired
renal function. As such, SGLT2i are not
recommended for patients with advanced
CKD.
Objective: This
systematic review aims at looking at the
effects of SGLT2i in adult patients with
Type 2 diabetes and chronic kidney disease.
Methods:
We searched Cochrane Central Register
of Controlled Trials, PubMed, MEDLINE,
and Google Scholar to identify various
trials, which had reported renal outcome
trials for SGLT2i. The reviewers examined
renal outcomes, which were end-stage renal
disease (ESRD), renal failure, doubling
serum creatinine, macroalbuminuria, incident
microalbuminuria, alteration in urine
albumin-to-creatinine ratio (UACR), estimated
glomerular filtrate rate (eGFR), dialysis,
kidney transplant, or death related to
renal disease. The extracted data were
qualitatively synthesized.
Results:18
studies that met the eligibility criteria
were selected for review. In line with
the strong evidence presented in previous
meta-analyses, SGLT2i clearly demonstrated
that it lowered the risk of developing
ESRD, microalbuminuria, and reduced the
levels of eGFR and UACR compared to controls.
Conclusion:
SGLT2i has positive renoprotective
effects in patients with T2DM and CKD
by reducing the risk of developing worsening
albuminuria and decreasing the risk for
ESRD compared to controls.
Key words:
randomized controlled trial, RCT,
type 2 diabetes mellitus, T2DM,
odium-glucose cotransporter 2 inhibitors,
SGLT2, canagliflozin, dapagliflozin, empagliflozin,
ertugliflozin, albuminuria , renal failure,
chronic kidney disease, end-stage renal
failure
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