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April 2022 -
Volume 20, Issue 4


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From the Editor

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Prevalence of Anxiety and Depression among postgraduate trainees in Qassim, Saudi Arabia
[Abstract]
[pdf]
Jamal Alrasheedi, Unaib Rabbani
DOI: 10.5742/MEWFM.2022.9525020

Knowledge of Amblyopia among Primary Health Care Physicians and Family Medicine Residents: A Cross-Sectional Study in the Qassim Region of Saudi Arabia
[Abstract]
[pdf]
Noha Dekhail Aldekhail, Amel Abdalrahim Sulaiman
OI: 10.5742/MEWFM.2022.9525022

Acute chest syndrome and pulmonary hypertension in sickle cell diseases
Mehmet Rami Helvaci, Engin Altintas, Atilla Yalcin, Orhan Ekrem Muftuoglu,
Abdulrazak Abyad, Lesley Pocock
[Abstract]
[pdf]
DOI: 10.5742/MEWFM.2022.9525023

Barriers Facing Primary Health Care Physicians in Jazan when Dealing with Emergency Cases
[Abstract]
[pdf]
Sameer Ahmed Ali Holal, Hassan Ali Elsayed Abdelwahid
DOI: 10.5742/MEWFM.2022.9525028

Predictors of Waterpipe Smoking among Male Students of Jazan University, Jazan, Saudi Arabia
[Abstract]
[pdf]
Mohammed Ahmed Khormi, Abdullah Ibrahim Sabai, Ali Yahya Maashi, Mohammed Abduallh Khormi,
Abdulrahman Ahmed hadadi, Abdullatif Mohammed Maashi, Mohammed Ebrahim Mojiri,
Ali Ahmed Zalah, Mohammed Abkar Shok, Ali Mohammed Shawsh
DOI: 10.5742/MEWFM.2022.9525037

Children's vision health during the COVID-19 pandemic
[Abstract]
[pdf]
Moustafa Abdalhade Timorkhan, Mouazzar yusuf Thani Ibraheem
DOI: 10.5742/MEWFM.2022.9525024

Multiple myeloma presenting as a pathological rib fracture in a primary health care center and its diagnostic challenges during the COVID 19 pandemic
[Abstract]
[pdf]
Koshy Mathew, Fathima Shezoon Mohideen, Prince Christopher Rajkumar Honest
DOI: 10.5742/MEWFM.2022.9525025

The association between sleep disturbance and coronaphobia among physicians in primary health care centers of Ministry of Health, Jazan Province
[Abstract]
[pdf]
Mohammed Atiah Ahmed Bakri, Maged El-Setouhy
DOI: 10.5742/MEWFM.2022.9525026

Population and Community Studies

What it costs to access skilled birth attendance in Pakistan
[Abstract]
[pdf]
Nida Khan, Muhammad Amir Khan, Shaheer Ellahi Khan, Muhammad Ahmar Khan, Azza Warraitch
DOI: 10.5742/MEWFM.2022.9525027

Complementary and alternative medicine practice and perceptions of Saudi subjects in Western region of Saudi Arabia
[Abstract]
[pdf]
Fathi El-Gamal, Abdulaziz Bajubair, Aljawhara Hejji, Aseel Jarwan, Jamil Numan Salah
DOI: 10.5742/MEWFM.2022.9525029

Prevalence of physical and verbal violence against physicians and nurses in primary health care centres, Buraidah, Qassim province
[Abstract]
[pdf]
Moodhi. R. Almutairi, Saulat. Jahan
DOI: 10.5742/MEWFM.2022.9525038

Assessment of Food Safety Knowledge & practice and Factors that May affect them among General Population at Family Medicine Outpatient clinic
[Abstract]
[pdf]
Heba Galal Elnahas, Ghada M. Khafagy, Eman M. Abd el-Sattar, Radwa M. Elsayed
DOI: 10.5742/MEWFM.2022.9525039

Middle East Quality Improvement Program
(MEQUIP QI&CPD)


Chief Editor -
Abdulrazak Abyad MD, MPH, MBA, AGSF, AFCHSE

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Publisher -
Lesley Pocock
medi+WORLD International
AUSTRALIA
Email
: lesleypocock@mediworld.com.au
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April 2022 - Volume 20, Issue 4

Acute chest syndrome and pulmonary hypertension in sickle cell diseases

(1) Specialist of Internal Medicine, MD
(2) Middle-East Academy for Medicine of Aging, MD
(3) medi-WORLD International

Corresponding author:
Prof Dr Mehmet Rami Helvaci,
Alanya, Antalya,
Turkey
Phone: 00-90-506-4708759
Email: mramihelvaci@hotmail.com

Received: February 2022 Accepted: March 2022; Published: April 1, 2022. Citation: Mehmet Helvaci et al. Acute chest syndrome and pulmonary hypertension in sickle cell diseases. World Family Medicine. 2022; 20(4): 22-31. DOI: 10.5742/MEWFM.2022.9525023

Abstract


Background: Sickle cell diseases (SCD) are severe inflammatory processes on vascular endothelium, particularly at the capillary level since the capillary system is the main distributor of hardened red blood cells (RBC) into tissues.

Methods: All patients with the SCD were included.

Results: The study included 222 males and 212 females with similar mean ages (30.8 versus 30.3 years, p>0.05, respectively). Smoking (23.8% versus 6.1%, p<0.001), alcohol (4.9% versus 0.4%, p<0.001), disseminated teeth losses (5.4% versus 1.4%, p<0.001), ileus (7.2% versus 1.4%, p<0.001), cirrhosis (8.1% versus 1.8%, p<0.001), leg ulcers (19.8% versus 7.0%, p<0.001), digital clubbing (14.8% versus 6.6%, p<0.001), coronary heart disease (CHD) (18.0% versus 13.2%, p<0.05), chronic renal disease (CRD) (9.9% versus 6.1%, p<0.05), chronic obstructive pulmonary disease (COPD) (25.2% versus 7.0%, p<0.001), and stroke (12.1% versus 7.5%, p<0.05) were higher in males but not acute chest syndrome (ACS) (2.7% versus 3.7%), pulmonary hypertension (PHT) (12.6% versus 11.7), and deep venous thrombosis and/or varices and/or telangiectasias (9.0% versus 6.6%), significantly (p>0.05 for all). Mean ages of ACS and PHT were 30.3 and 34.0 years (p<0.05), respectively.

Conclusion: Although smoking, alcohol, disseminated teeth losses, ileus, cirrhosis, leg ulcers, digital clubbing, CHD, CRD, COPD, and stroke-like atherosclerotic events were higher in males, and the male sex alone is a risk factor for atherosclerosis, ACS and PHT were similar in both genders, and mean age of PHT is much higher than ACS, significantly. In other words, PHT may have a hardened RBC-induced chronic, whereas ACS an acute thromboembolic background, in the SCD.

Key words: Sickle cell diseases, acute chest syndrome, pulmonary hypertension, thromboembolism, chronic endothelial damage, atherosclerosis, metabolic syndrome







 


 

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