JOURNAL
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June 2023 -
Volume 21, Issue 5


View this issue in pdf format

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From the Editor

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Original Contribution

Exclusive breastfeeding for the first six months after birth: A cross-sectional study in health care centers in Khartoum, Sudan
[Abstract]
[pdf]
Walid Tawfig, Lateefa Othman Aldakhil
DOI: 10.5742/MEWFM.2023.95256105

Prevalence and ultrasound features of polycystic ovaries in young females examined by pelvic ultrasound in primary health care in Qatar. Electronic Medical record-based study
[Abstract]
[pdf]
Tamer F. Ali, Abdelwahed Samir Abougazia
DOI: 10.5742/MEWFM.2023.95256106

Venous Thromboembolism Awareness among Saudis Risk Group at Primary Health Care Centers in Riyadh
[Abstract]
[pdf]
Afaf Hakami, Hessa Almutairi, Mashael Alqwaiee, Fatemah Altheyab, Hanan Abuhaimid, Wejdan makrami, Maryam Almatrafi, Nadiah Alanazi, Huda Almofrih, Nora Alheleel, Nouf Al-Helail
DOI: 10.5742/MEWFM.2023.95256107

Prevalence of Colonic Diverticulosis among Adult patients with Obesity and metabolic syndrome conditions, a Retrospective Study at a University Hospital in Saudi Arabia
[Abstract]
[pdf]
Hani Jawa, Mohammed Alfawaz, Waleed Alghamdi, Almoutaz Hashim, Enad Alsolami, Faisal Aljehani Meshari Abdulaziz Althobaiti, Fayafi Nidhal Alghazzawi, Reem Abdulraouf Ghaza, Lama Abdulmuti Alharbi, Muath Saeed Alharbi
DOI: 10.5742/MEWFM.2023.95256108

Acute painful crises may be causes of sudden deaths in sickle cell diseases
[Abstract]
[pdf]
Mehmet Rami Helvaci, Mehpare Camlibel, Burcu Yuksek, Alper Sevinc,
Celaletdin Camci, Abdulrazak Abyad, Lesley Pocock
DOI: 10.5742/MEWFM.2023.95256109

Use of Uterine and Ovarian Arteries Doppler Parameters for the Prediction of Infertility in Females
[Abstract]
[pdf]
Syed Muhammad Yousaf Farooq, Nazish Zulfiqar, Meryem Zulfiqar,
Syed Amir Gilani, Zareen Fatima, Asif Hanif, Amer Akhter
DOI: 10.5742/MEWFM.2023.95256113

Review

Role of glucagon-like peptide-1 analogues in weight management
[Abstract]
[pdf]
Bilal Hasan Chaudhry, Laith AlMarsomi
DOI: 10.5742/MEWFM.2023.95256110

Helicobacter Pylori infection; the challenging task of improving eradication rates in light of rising antibiotic resistance, a literature review
[Abstract]
[pdf]
Asad Islam
DOI: 10.5742/MEWFM.2023.95256112

Regional Covid

Effect of COVID-19 lock down on development of infants and toddlers
[Abstract]
[pdf]
Muhammad Qaisar Jamal Khattak, Bilal Hasan Chaudhry
DOI: 10.5742/MEWFM.2023.95256114

 

 

 

Middle East Quality Improvement Program
(MEQUIP QI&CPD)


Chief Editor -
Abdulrazak Abyad MD, MPH, MBA, AGSF, AFCHSE

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Publisher -
Lesley Pocock
medi+WORLD International
AUSTRALIA
Email
: lesleypocock@mediworld.com.au
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June 2023- Volume 21, Issue 5

Acute painful crises may be causes of sudden deaths in sickle cell diseases

(1) Specialist of Internal Medicine, MD, Turkey
(2) Specialist of Emergency Medicine, MD, Turkey
(3) Manager of Writing and Statistics, Turkey
(4) Middle-East Academy for Medicine of Aging, MD, Lebanon
(5) Medi-WORLD International, Australia

Corresponding author:

Prof Dr Mehmet Rami Helvaci, MD
07400, ALANYA, Turkey
Phone: 00-90-506-4708759
Email: mramihelvaci@hotmail.com

Received: April 2023. Accepted: May 2023; Published: June 1, 2023.Citation: Helvaci M R et al. Acute painful crises may be causes of sudden deaths in sickle cell diseases. World Family Medicine. June 2023; 21(5): 37-49 DOI: 10.5742/MEWFM.2023.95256109

Abstract

Background: Sickle cell diseases (SCDs) are severe inflammatory processes on vascular endothelium, especially at the capillary level because the capillary system is the actual distributor of hardened red blood cells (RBCs) into the tissues.

Methods: All cases with the SCDs were included.

Results: We studied 222 males and 212 females with similar mean ages (30.8 vs 30.3 years, p>0.05, respectively). Disseminated teeth losses (5.4% vs 1.4%, p<0.001), ileus (7.2% vs 1.4%, p<0.001), cirrhosis (8.1% vs 1.8%, p<0.001), leg ulcers (19.8% vs 7.0%, p<0.001), digital clubbing (14.8% vs 6.6%, p<0.001), coronary heart disease (18.0% vs 13.2%, p<0.05), chronic renal disease (9.9% vs 6.1%, p<0.05), chronic obstructive pulmonary disease (25.2% vs 7.0%, p<0.001), and stroke (12.1% vs 7.5%, p<0.05) were all higher in males but not acute chest syndrome (2.7% vs 3.7%), pulmonary hypertension (12.6% vs 11.7), deep venous thrombosis and/or varices and/or telangiectasias (9.0% vs 6.6%), or mean age of mortality (30.2 vs 33.3 years) (p>0.05 for all).

Conclusion: The hardened RBCs-induced capillary endothelial damage, inflammation, edema, and fibrosis are initiated at birth, and terminate with disseminated tissue hypoxia and multiorgan failures even at childhood in the SCDs. Although RBCs supports and corticosteroids in acute phase and aspirin plus hydroxyurea both in acute and chronic phases decrease severity of the diseases, survivals are still shortened in both genders, dramatically. Infections, medical or surgical emergencies, or emotional stresses-induced increased basal metabolic rate aggravates the sickling and capillary endothelial edema, and may terminate with acute painful crises, multiorgan failures, and sudden deaths.

Key words: Sickle cell diseases, acute painful crises, sudden deaths, capillary endothelial inflammation, capillary endothelial edema, atherosclerosis, aging