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Abstract
Background: We
tried to understand some unknown functions
of plasma triglycerides.
Methods: Patients
with plasma triglycerides lower than 60
mg/dL were put into the first, lower than
100 mg/dL into the second, lower than
150 mg/dL into the third, lower than 200
mg/dL into the fourth, and 200 mg/dL or
higher into the fifth groups, respectively.
Results: The
study included 875 cases (505 females),
totally. Mean age increased up to the
plasma triglycerides value of 200 mg/dL,
and there was an increase of triglycerides
about 7.8 mg/dL for each year of aging.
Whereas male ratio increased parallel
to the increased plasma values of triglycerides,
continuously (30.9% versus 51.2%, p<0.001).
Mean Body Mass Index (BMI) was 24.6, 27.1,
29.4, 29.9, and 30.0 kg/m2 in the five
groups, respectively, and it was only
normal in patients with plasma triglycerides
values lower than 60 mg/dL. Fasting plasma
glucose (FPG), hypertension (HT), diabetes
mellitus (DM), smoking, chronic obstructive
pulmonary disease (COPD), and chronic
renal disease (CRD) increased parallel
to the increased triglycerides, continuously.
Whereas low density lipoproteins (LDL),
white coat hypertension (WCH), and coronary
heart disease (CHD) increased just up
to plasma triglycerides value of 200 mg/dL.
Conclusions:
Plasma triglycerides may behave as acute
phase reactants indicating disseminated
endothelial damage, inflammation, fibrosis,
and eventual atherosclerosis all over
the body. Interestingly, parallel to the
increased plasma triglycerides values,
significant deterioration was observed
regarding the components of the metabolic
syndrome including mean age, male gender,
smoking, BMI, FPG, LDL, WCH, HT, DM, COPD,
CHD and CRD.
Key words:
Triglycerides, acute phase reactants,
smoking, male gender, excess weight, aging,
chronic endothelial damage, accelerated
atherosclerosis
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