Middle East Journal of Family Medicine

JOURNAL

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April 2023 - Volume 21, Issue 3
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From the Editor

Editorial
A. Abyad (Chief Editor)
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Email: amcmeli@gmail.com, aabyad@cyberia.net.lb

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Lesley Pocock
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Editorial
Abdulrazak Abyad

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Middle East Quality Improvement Program
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Abdulrazak Abyad MD, MPH, MBA, AGSF, AFCHSE
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April 2023- Volume 21, Issue 3

Collagen-Based Grafts and Autologous Dura Replacement in Patients with Dura Abnormalities: A Retrospective Comparative Evaluation

Zahra Mannan Waheed1, Saima Firdous2, Fahad Rafiq Butt3, Sana Afzal Khan1,
Chinonso Ndubuisi4, Abrar Hussain5

(1) Fellow Anesthesia, Shaukat Khanum Memorial Cancer Hospital and Research Center, Pakistan
(2) Department of Zoology, Kohat University of Science and Technology, Kohat, Pakistan (ORCID: 0009-0008-8150-1697)
(3) Locum Consultant, Shaukat Khanum Memorial Cancer Hospital and Research Center, Pakistan
(4) Department of Family Medicine, Humboldt Park Health, Chicago, USA (ORCID: 0000-0001-6793-7031)
(5) Department of Biological Sciences, International Islamic University, Islamabad, Pakistan

Corresponding author:
Fahad Rafiq Butt,
Locum Consultant,
Shaukat Khanum Memorial Cancer Hospital and Research Center,
Pakistan
Email: fahadrafiq@skm.org.pk

Received: February 2023; Accepted: March 2023; Published: April 1, 2023. Citation: Zahra Mannan Waheed et al. Collagen-Based Grafts and Autologous Dura Replacement in Patients with Dura Abnormalities: A Retrospective Comparative Evaluation. World Family Medicine. March 2023; 21(3): 19-23 DOI: 10.5742/MEWFM.2023.95256069

Abstract

Introduction: Accidental spinal anomalies of the spinal dura mater are the source of cerebrospinal fluid (CSF) leakage. Typically, dura abnormalities are identified in 3 percent of endoscopic lumbar discectomy cases.

Objective: The purpose of the current research was to evaluate the results of autologous dura replacement versus collagen-based grafts in individuals with dura deformities.

Methods: The Institute of Neurosurgery at Liaquat National Hospital Karachi undertook this randomized evaluation to identify the most effective therapy for dura mater defects. Employing non-probability random selection, 82 cases among both sexes were selected. Participants were divided randomly into two subgroups i.e. Group 1A received an autologous graft for dura restoration, whereas Group 2B received a semi-synthetic dura replacement. A skilled surgeon led a medical team of six people who completed the entire process.

Results: The operation duration for semi-synthetic collagen was significantly reduced. There was a 40 minute variation in total time spent by the two groups. Autologous grafts showed ideal tightness and better flexibility and fair workability on the other hand semi-synthetic collagen showed better tightness and workability and ideal flexibility. Postoperative hospital stays were seen to be 26 + 2.5 hours in Group 1A whereas they were 23 + 2.5 hours for Group B.

Conclusion: According to the aforementioned findings, an accessible, secure, and efficient substitution for an autologous graft for dura restoration in dura abnormalities is the use of a semi-synthetic collagen substitute.

Keywords: semi-synthetic collagen substitute, cerebrospinal fluid, dura abnormalities, autologous graft.

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