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March 2022 -
Volume 20, Issue 3


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From the Editor

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Prevalence of depression and anxiety among patients with breast cancer: a cross-sectional study
[Abstract]
[pdf]
Abbas Bukhari, Ali Farsi, Fawaz Albaqami, Abdulaziz Jowharji, Mansoor Radwi, Abdalmohsen Albaqami, Mohammed Fallatah, Abdullah Alammari, Waleed Alghamdi
DOI: 10.5742/MEWFM.2022.952506

Women's Expectations and Satisfaction with the Quality of Antenatal Care at the Primary Health Care Centers in Unaizah City
[Abstract]
[pdf]
Sadeem Alrobiaee, Saulat Jahan
DOI: 10.5742/MEWFM.2022.952507

Pulmonary hypertension and chronic obstructive pulmonary disease in sickle cell diseases
[Abstract]
[pdf]
Mehmet Rami Helvaci, Engin Altintas, Atilla Yalcin, Orhan Ekrem Muftuoglu,
Abdulrazak Abyad, Lesley Pocock
DOI: 10.5742/MEWFM.2022.952508

Positive and negative acute phase reactants in sickle cell diseases
[Abstract]
[pdf]
Mehmet Rami Helvaci, Engin Altintas, Atilla Yalcin, Orhan Ekrem Muftuoglu, Abdulrazak Abyad, Lesley Pocock
DOI: 10.5742/MEWFM.2022.952509

Population and Community Studies

An Overview of Biological Warfare and SARS-CoV-2 as a Potential Biological Agent
[Abstract]
[pdf]
Basem Mohammad Mansour, Deaa Mohammad Alsoleman, Suhail Haydar Alghanem
DOI: 10.5742/MEWFM.2022.9525010

Clinical Audit on Well Baby Services at Primary Health Care Corporation, Qatar
[Abstract]
[pdf]
Noora Alkubaisi, Ansif Pallath Majeed, Hanan Al Mujalli, Abdul Ali Shah,
Sharifullah Khan, Manickavalli M S Anand, Mohammed Asif AbdulGafoor
DOI: 10.5742/MEWFM.2022.9525012

Letter to the Editor

MENA Stem Cells Forum

News Alert

Fake Covid vaccine found in Iran - and beyond?
[Abstract]
[pdf]
Lesley Pocock
DOI: 10.5742/MEWFM.2022.9525016

Review


Cystic Fibrosis: A Review Article
[Abstract]
[pdf]
Hani Raka Karrar, Mahmoud Ismail Nouh, Abdulmohsen Aqeel G. Alanazi,
Sultan Essa Alharbi, Fahad Nuwayfi Almutairi, Hussain Ali Abdullah Alhammad,
Abdullah Ali Hassan Sadeeg, Mohammed Aljunaid Alamin Alsheikh,
Wafa mohammed alshaikh, Mohammed yousef Alyahya, Wejdan Ali Sulieman makki, Hashima Mohammed Alhazmi,
Amal saleem Almutairi, Rehab Salah Aldin Alhendi
DOI: 10.5742/MEWFM.2022.9525014

Case Report

Early-onset CTCL, localized and unilateral - case review

[Abstract]
[pdf]
Ebtisam Elghblawi
DOI: 10.5742/MEWFM.2022.9525015

Original Clinical Research

Study the clinical futures of vitiligo among Yemeni patients in Aden
[Abstract]
[pdf]
Asia Hassan Abdulla Saleh, Amer Bin Al-Zou
DOI: 10.5742/MEWFM.2022.9525017

Surgical treatment and Survival of Gallbladder Cancer Patients: A Systematic Review
[Abstract]
[pdf]
Ali Ibrahim A. Alshehri
DOI: 10.5742/MEWFM.2022.9525019

Shared Decision-Making and its Impact on Medication Adherence among Hypertensive Patients in Northern Saudi Arabia
[Abstract]
[pdf]
Mutasim Almuayqil, Abdusalam Alghamdi, Fahad Alruwaili, Nashmi Al-Etesh
DOI: 10.5742/MEWFM.2022.9525020

Middle East Quality Improvement Program
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Chief Editor -
Abdulrazak Abyad MD, MPH, MBA, AGSF, AFCHSE

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medi+WORLD International
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March 2022 - Volume 20, Issue 3

Positive and negative acute phase reactants in sickle cell diseases

(1) Specialist of Internal Medicine, MD
(2) Middle-East Academy for Medicine of Aging, MD
(3) Medi-WORLD International

Corresponding author:
Prof Dr Mehmet Rami Helvaci,
ALANYA, Antalya, TurkeyPhone: 00-90-506-4708759
Email: mramihelvaci@hotmail.com

Received: January 2022; Accepted: February 2022; Published: March 1, 2022. Citation: Mehmet Rami Helvaci et al. Positive and negative acute phase reactants in sickle cell diseases. World Family Medicine. 2022; 20(3): 36-42. DOI: 10.5742/MEWFM.2022.952509

Abstract


Background: We tried to understand some positive and negative acute phase reactants (APR) in sickle cell diseases (SCD).

Methods: Consecutive patients with the SCD and controls were studied.

Results: The study included 193 patients (98 females) and 132 controls (67 females). Although the body weight and body mass index (BMI) were retarded in the SCD (58.9 versus 71.1 kg and 21.5 versus 26.8 kg/m2, respectively, p<0.000 for both), the body heights were similar in both groups (164.8 versus 162.8 cm, p>0.05). Parallel to the retarded body weight and BMI, fasting plasma glucose (FPG) (93.4 versus 102.4 mg/dL, p=0.025), low density lipoproteins (LDL) (70.4 versus 98.1 mg/dL, p<0.000), high density lipoproteins (HDL) (24.2 versus 35.8 mg/dL, p<0.000), and systolic (117.6 versus 127.9 mmHg, p=0.001) and diastolic blood pressures (BP) (77.3 versus 86.0 mmHg, p<0.000) were all retarded in the SCD. On the other hand, total bilirubin (TB) and lactate dehydrogenase (LDH) were both increased (4.0 versus 0.7 mg/dL and 638.9 versus 268.4 U/L, respectively, p<0.000 for both) in the SCD. Similarly, white blood cell (WBC) and platelet (PLT) counts (16.338 versus 7.407 /µL and 421.424 versus 268.612 /µL, respectively) and mean corpuscular volume (MCV) (90.3 versus 78.3 fL) were all increased whereas the hematocrit (Hct) level was decreased (23.2 versus 36.6%) in the SCD (p<0.000 for all).

Conclusion: Body weight, BMI, FPG, LDL, HDL, systolic and diastolic BP, and Hct may be some negative whereas TB, LDH, WBC and PLT counts, and MCV may be some positive APR in the body.

Keywords: Sickle cell diseases, positive acute phase reactants, negative acute phase reactants, chronic endothelial damage, atherosclerosis, body weight, body mass index

 







 


 

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