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March 2022 -
Volume 20, Issue 3


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From the Editor

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Prevalence of depression and anxiety among patients with breast cancer: a cross-sectional study
[Abstract]
[pdf]
Abbas Bukhari, Ali Farsi, Fawaz Albaqami, Abdulaziz Jowharji, Mansoor Radwi, Abdalmohsen Albaqami, Mohammed Fallatah, Abdullah Alammari, Waleed Alghamdi
DOI: 10.5742/MEWFM.2022.952506

Women's Expectations and Satisfaction with the Quality of Antenatal Care at the Primary Health Care Centers in Unaizah City
[Abstract]
[pdf]
Sadeem Alrobiaee, Saulat Jahan
DOI: 10.5742/MEWFM.2022.952507

Pulmonary hypertension and chronic obstructive pulmonary disease in sickle cell diseases
[Abstract]
[pdf]
Mehmet Rami Helvaci, Engin Altintas, Atilla Yalcin, Orhan Ekrem Muftuoglu,
Abdulrazak Abyad, Lesley Pocock
DOI: 10.5742/MEWFM.2022.952508

Positive and negative acute phase reactants in sickle cell diseases
[Abstract]
[pdf]
Mehmet Rami Helvaci, Engin Altintas, Atilla Yalcin, Orhan Ekrem Muftuoglu, Abdulrazak Abyad, Lesley Pocock
DOI: 10.5742/MEWFM.2022.952509

Population and Community Studies

An Overview of Biological Warfare and SARS-CoV-2 as a Potential Biological Agent
[Abstract]
[pdf]
Basem Mohammad Mansour, Deaa Mohammad Alsoleman, Suhail Haydar Alghanem
DOI: 10.5742/MEWFM.2022.9525010

Clinical Audit on Well Baby Services at Primary Health Care Corporation, Qatar
[Abstract]
[pdf]
Noora Alkubaisi, Ansif Pallath Majeed, Hanan Al Mujalli, Abdul Ali Shah,
Sharifullah Khan, Manickavalli M S Anand, Mohammed Asif AbdulGafoor
DOI: 10.5742/MEWFM.2022.9525012

Letter to the Editor

MENA Stem Cells Forum

News Alert

Fake Covid vaccine found in Iran - and beyond?
[Abstract]
[pdf]
Lesley Pocock
DOI: 10.5742/MEWFM.2022.9525016

Review


Cystic Fibrosis: A Review Article
[Abstract]
[pdf]
Hani Raka Karrar, Mahmoud Ismail Nouh, Abdulmohsen Aqeel G. Alanazi,
Sultan Essa Alharbi, Fahad Nuwayfi Almutairi, Hussain Ali Abdullah Alhammad,
Abdullah Ali Hassan Sadeeg, Mohammed Aljunaid Alamin Alsheikh,
Wafa mohammed alshaikh, Mohammed yousef Alyahya, Wejdan Ali Sulieman makki, Hashima Mohammed Alhazmi,
Amal saleem Almutairi, Rehab Salah Aldin Alhendi
DOI: 10.5742/MEWFM.2022.9525014

Case Report

Early-onset CTCL, localized and unilateral - case review

[Abstract]
[pdf]
Ebtisam Elghblawi
DOI: 10.5742/MEWFM.2022.9525015

Original Clinical Research

Study the clinical futures of vitiligo among Yemeni patients in Aden
[Abstract]
[pdf]
Asia Hassan Abdulla Saleh, Amer Bin Al-Zou
DOI: 10.5742/MEWFM.2022.9525017

Surgical treatment and Survival of Gallbladder Cancer Patients: A Systematic Review
[Abstract]
[pdf]
Ali Ibrahim A. Alshehri
DOI: 10.5742/MEWFM.2022.9525019

Shared Decision-Making and its Impact on Medication Adherence among Hypertensive Patients in Northern Saudi Arabia
[Abstract]
[pdf]
Mutasim Almuayqil, Abdusalam Alghamdi, Fahad Alruwaili, Nashmi Al-Etesh
DOI: 10.5742/MEWFM.2022.9525020

Middle East Quality Improvement Program
(MEQUIP QI&CPD)


Chief Editor -
Abdulrazak Abyad MD, MPH, MBA, AGSF, AFCHSE

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medi+WORLD International
AUSTRALIA
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March 2022 - Volume 20, Issue 3

Pulmonary hypertension and chronic obstructive pulmonary disease in sickle cell diseases

(1) Specialist of Internal Medicine, MD
(2) Middle-East Academy for Medicine of Aging, MD
(3) Medi-WORLD International

Corresponding author:
Prof Dr Mehmet Rami Helvaci,
ALANYA, Antalya, TurkeyPhone: 00-90-506-4708759
Email: mramihelvaci@hotmail.com

Received: January 2022 Accepted: February 2022; Published: March 1, 2022. Citation: Mehmet Rami Helvaci et al. Pulmonary hypertension and chronic obstructive pulmonary disease in sickle cell diseases. World Family Medicine. 2022; 20(3): 27-35. DOI: 10.5742/MEWFM.2022.952508

Abstract


Background: Pulmonary hypertension (PHT) is a common consequence of chronic obstructive pulmonary disease (COPD).

Methods: All patients with sickle cell diseases (SCD) were included.

Results: The study included 434 patients (212 females) with similar mean ages in males and females (30.8 versus 30.3 years, p>0.05, respectively). Smoking (23.8% versus 6.1%, p<0.001), alcohol (4.9% versus 0.4%, p<0.001), disseminated teeth losses (<20 teeth present) (5.4% versus 1.4%, p<0.001), ileus (7.2% versus 1.4%, p<0.001), cirrhosis (8.1% versus 1.8%, p<0.001), leg ulcers (19.8% versus 7.0%, p<0.001), digital clubbing (14.8% versus 6.6%, p<0.001), coronary heart disease (CHD) (18.0% versus 13.2%, p<0.05), chronic renal disease (CRD) (9.9% versus 6.1%, p<0.05), stroke (12.1% versus 7.5%, p<0.05), and COPD (25.2% versus 7.0%, p<0.001) were higher but not PHT (12.6% versus 11.7, p>0.05) and deep venous thrombosis (DVT) and/or varices and/or telangiectasias (9.0% versus 6.6%, p>0.05) in males.

Conclusion: SCD are severe inflammatory processes on vascular endothelium, particularly at the capillary level since the capillary system is the main distributor of hardened red blood cells (RBC) into tissues. Although smoking, alcohol, disseminated teeth losses, ileus, cirrhosis, leg ulcers, digital clubbing, CHD, CRD, stroke, and COPD-like atherosclerotic events were higher in males, PHT and DVT and/or varices and/or telangiectasias were similar in both genders. Similarly, although the male gender alone is a risk factor for the systemic atherosclerosis, the similar prevalence of PHT in both genders also supports its nonatherosclerotic nature. In another definition, COPD may have an atherosclerotic whereas PHT a hardened RBC-induced chronic thromboembolic background in the SCD.

Key words: Sickle cell diseases, pulmonary hypertension, chronic obstructive pulmonary disease, endothelial damage, atherosclerosis, metabolic syndrome, aging







 


 

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